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TargetReceptor-interacting serine/threonine-protein kinase 2
LigandBDBM50574922
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2123711 (CHEMBL4832944)
IC50 5.0±n/a nM
Citation Miah, AH; Smith, IED; Rackham, M; Mares, A; Thawani, AR; Nagilla, R; Haile, PA; Votta, BJ; Gordon, LJ; Watt, G; Denyer, J; Fisher, DT; Dace, P; Giffen, P; Goncalves, A; Churcher, I; Scott-Stevens, P; Harling, JD Optimization of a Series of RIPK2 PROTACs. J Med Chem64:12978-13003 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 2
Name:Receptor-interacting serine/threonine-protein kinase 2
Synonyms:CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50574922
n/a
NameBDBM50574922
Synonyms:CHEMBL4872212
TypeSmall organic molecule
Emp. Form.C55H67FN8O11S3
Mol. Mass.1131.361
SMILESCN[C@@H](C)C(=O)N[C@@H](C1CCN(CC1)C(=O)COCCOCCOCCOCCOc1cc2nccc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 |r|
Structure
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