| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
|---|
| Ligand | BDBM50574934 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2123717 (CHEMBL4832950) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Miah, AH; Smith, IED; Rackham, M; Mares, A; Thawani, AR; Nagilla, R; Haile, PA; Votta, BJ; Gordon, LJ; Watt, G; Denyer, J; Fisher, DT; Dace, P; Giffen, P; Goncalves, A; Churcher, I; Scott-Stevens, P; Harling, JD Optimization of a Series of RIPK2 PROTACs. J Med Chem64:12978-13003 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase XIAP |
|---|
| Name: | E3 ubiquitin-protein ligase XIAP |
|---|
| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56685.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P98170 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
|
|
|
|---|
| BDBM50574934 |
|---|
| n/a |
|---|
| Name | BDBM50574934 |
|---|
| Synonyms: | CHEMBL4876228 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C54H67FN14O7S2 |
|---|
| Mol. Mass. | 1107.328 |
|---|
| SMILES | CN[C@@H](C)C(=O)N[C@@H](C1CCN(CC1)C(=O)c1cnc(cn1)N1CCN(CCCOc2cc3ncnc(Nc4n[nH]c(C)c4C)c3cc2S(=O)(=O)C(C)(C)C)CC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
