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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nitric oxide synthase, brain | ||
| Ligand | BDBM50141079 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_143351 (CHEMBL750652) | ||
| IC50 | 96.3±n/a nM | ||
| Citation |  Lowe, JA; Qian, W; Drozda, SE; Volkmann, RA; Nason, D; Nelson, RB; Nolan, C; Liston, D; Ward, K; Faraci, S; Verdries, K; Seymour, P; Majchrzak, M; Villalobos, A; White, WF Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure. J Med Chem47:1575-86 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nitric oxide synthase, brain | |||
| Name: | Nitric oxide synthase, brain | ||
| Synonyms: | Constitutive NOS | N-NOS | NC-NOS | NOS type I | NOS type I nNOS | NOS1 | NOS1_HUMAN | Neuronal NOS | Neuronal nitric oxide synthase | Nitric oxide synthase, brain (nNOS) | Nitric oxide synthase, neuronal (nNOS) | Peptidyl-cysteine S-nitrosylase NOS1 | bNOS | nNOS | ||
| Type: | Homodimer | ||
| Mol. Mass.: | 160985.98 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29475 | ||
| Residue: | 1434 | ||
| Sequence: |
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| BDBM50141079 | |||
| n/a | |||
| Name | BDBM50141079 | ||
| Synonyms: | 6-[4-(1-Aza-bicyclo[2.2.2]oct-2-ylmethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | CHEMBL39186 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H25N3O | ||
| Mol. Mass. | 359.4641 | ||
| SMILES | Nc1cccc(n1)-c1ccc(OCC2CC3CCN2CC3)c2ccccc12 |(11.24,-2.54,;9.89,-1.75,;9.89,-.21,;8.56,.56,;7.23,-.21,;7.23,-1.75,;8.56,-2.52,;5.89,-2.52,;4.57,-1.75,;3.24,-2.52,;3.24,-4.06,;1.89,-4.85,;.57,-4.08,;-.76,-4.86,;-2.09,-4.08,;-3.43,-4.85,;-1.9,-4.84,;-2.3,-6.31,;-.76,-6.4,;-2.11,-7.17,;-3.44,-6.4,;4.57,-4.82,;4.57,-6.37,;5.89,-7.14,;7.23,-6.37,;7.23,-4.82,;5.89,-4.06,)| | ||
| Structure | 
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