| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM463446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2125494 (CHEMBL4834839) |
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| Ki | 1.6±n/a nM |
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| Citation |  Ferreira, MA; Azevedo, H; Mascarello, A; Segretti, ND; Russo, E; Russo, V; Guimarães, CRW Discovery of J Med Chem64:1904-1929 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM463446 |
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| n/a |
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| Name | BDBM463446 |
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| Synonyms: | US10781182, Compound IA2-142 | US11091445, Compound code IA2-142 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20ClN3O3 |
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| Mol. Mass. | 325.791 |
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| SMILES | CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O |
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| Structure | 
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