| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM50142492 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_158454 (CHEMBL763258) |
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| Ki | 4.9±n/a nM |
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| Citation |  Elworthy, TR; Kertesz, DJ; Kim, W; Roepel, MG; Quattrocchio-Setti, L; Smith, DB; Tracy, JL; Chow, A; Li, F; Brill, ER; Lach, LK; McGee, D; Yang, DS; Chiou, SS Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett14:1655-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 53134.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35408 |
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| Residue: | 488 |
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| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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| BDBM50142492 |
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| n/a |
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| Name | BDBM50142492 |
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| Synonyms: | 7-{(R)-2-[(E)-3-Hydroxy-3-(4'-hydroxy-2'-methyl-biphenyl-3-yl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | CHEMBL444574 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33NO5 |
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| Mol. Mass. | 451.5546 |
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| SMILES | Cc1cc(O)ccc1-c1cccc(c1)C(O)\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O |
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| Structure | 
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