| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
|---|
| Ligand | BDBM50576055 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2126428 (CHEMBL4835773) |
|---|
| IC50 | 220±n/a nM |
|---|
| Citation |  Spinck, M; Bischoff, M; Lampe, P; Meyer-Almes, FJ; Sievers, S; Neumann, H Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1. J Med Chem64:5838-5849 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD-dependent protein deacetylase sirtuin-1 |
|---|
| Name: | NAD-dependent protein deacetylase sirtuin-1 |
|---|
| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
|---|
| Type: | Developmental protein; hydrolase |
|---|
| Mol. Mass.: | 81626.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 747 |
|---|
| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
|
|
|
|---|
| BDBM50576055 |
|---|
| n/a |
|---|
| Name | BDBM50576055 |
|---|
| Synonyms: | CHEMBL4855963 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O2 |
|---|
| Mol. Mass. | 293.3199 |
|---|
| SMILES | NC(=O)C1CN(Cc2ccccc2C#N)c2ccccc2O1 |
|---|
| Structure | 
|
|---|
Search and Browse
