| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
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| Ligand | BDBM50576184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2126599 (CHEMBL4835944) |
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| Ki | 0.400000±n/a nM |
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| Citation |  Luo, G; Jiang, XJ; Chen, L; Conway, CM; Gulianello, M; Kostich, W; Keavy, D; Signor, LJ; Chen, P; Davis, C; Whiterock, VJ; Schartman, R; Widmann, KA; Macor, JE; Dubowchik, GM Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead. Bioorg Med Chem Lett43:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor |
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| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| BDBM50576184 |
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| n/a |
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| Name | BDBM50576184 |
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| Synonyms: | CHEMBL4877386 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27ClF3N7O4 |
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| Mol. Mass. | 618.007 |
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| SMILES | NC(=O)c1c[nH]c2c(Cl)cc3C[C@@H](CC(=O)N4CCC(CC4)n4c5cccnc5[nH]c4=O)C(=O)N(CC(F)(F)F)Cc3c12 |r| |
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| Structure | 
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