| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50576738 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2127757 (CHEMBL4837102) |
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| IC50 | 1.1±n/a nM |
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| Citation |  Sabnis, RW Novel Heterocyclic Compounds as Delta-5-Desaturase Inhibitors for Treating Metabolic and Cardiovascular Diseases. ACS Med Chem Lett12:1218-1219 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51985.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513296 |
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| Residue: | 444 |
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| Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
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| BDBM50576738 |
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| n/a |
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| Name | BDBM50576738 |
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| Synonyms: | CHEMBL4856454 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9F7N4O |
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| Mol. Mass. | 394.247 |
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| SMILES | Fc1ccc2nc(c(-c3cnn(CCC(F)(F)F)c3)c(=O)n2c1)C(F)(F)F |
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| Structure | 
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