| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent betaine transporter |
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| Ligand | BDBM50577072 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2129156 (CHEMBL4838585) |
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| IC50 | 9772±n/a nM |
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| Citation |  Zar?ba, P; Sa?at, K; Höfner, GC; ??tka, K; Bajda, M; Latacz, G; Kotniewicz, K; Rapacz, A; Podkowa, A; Maj, M; Jó?wiak, K; Filipek, B; Wanner, KT; Malawska, B; Kulig, K Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. Eur J Med Chem221:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent betaine transporter |
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| Name: | Sodium- and chloride-dependent betaine transporter |
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| Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69615.88 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460088 |
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| Residue: | 614 |
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| Sequence: | MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSS
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGR
RDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGW
LLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSP
AKQELIAWEKETHL
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| BDBM50577072 |
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| n/a |
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| Name | BDBM50577072 |
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| Synonyms: | CHEMBL4851621 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34N2O2 |
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| Mol. Mass. | 466.6139 |
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| SMILES | [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1\c2ccccc2-[#6]=[#6]-c2ccccc-12)-[#6](-[#6]-[#6]-[#8])-[#6](=O)-[#7]-[#6]-c1ccc(-[#6])cc1 |c:13| |
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| Structure | 
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