Reaction Details |
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Target | Sodium- and chloride-dependent betaine transporter |
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Ligand | BDBM50577081 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2129156 (CHEMBL4838585) |
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IC50 | 11749±n/a nM |
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Citation | Zar?ba, P; Sa?at, K; Höfner, GC; ??tka, K; Bajda, M; Latacz, G; Kotniewicz, K; Rapacz, A; Podkowa, A; Maj, M; Jó?wiak, K; Filipek, B; Wanner, KT; Malawska, B; Kulig, K Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. Eur J Med Chem221:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent betaine transporter |
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Name: | Sodium- and chloride-dependent betaine transporter |
Synonyms: | GABA transporter | GABA transporter 2 | Gabt2 | Gat-2 | Gat2 | S6A12_MOUSE | Slc6a12 |
Type: | PROTEIN |
Mol. Mass.: | 69615.88 |
Organism: | Mus musculus |
Description: | ChEMBL_1460088 |
Residue: | 614 |
Sequence: | MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
RFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGM
ASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSS
SENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVY
FTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQG
CLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGP
GLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGR
RDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADR
FYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGW
LLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSP
AKQELIAWEKETHL
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BDBM50577081 |
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n/a |
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Name | BDBM50577081 |
Synonyms: | CHEMBL4852705 |
Type | Small organic molecule |
Emp. Form. | C30H34FN3O |
Mol. Mass. | 471.6089 |
SMILES | [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6]-c1ccc(F)cc1 |
Structure |
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