Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 1 |
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Ligand | BDBM50039251 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2129175 (CHEMBL4838604) |
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IC50 | 37±n/a nM |
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Citation | Zar?ba, P; Sa?at, K; Höfner, GC; ??tka, K; Bajda, M; Latacz, G; Kotniewicz, K; Rapacz, A; Podkowa, A; Maj, M; Jó?wiak, K; Filipek, B; Wanner, KT; Malawska, B; Kulig, K Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity. Eur J Med Chem221:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 1 |
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Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1472611 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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BDBM50039251 |
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n/a |
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Name | BDBM50039251 |
Synonyms: | (R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)piperidine-3-carboxylic acid hydrochloride | (R)-1-[4,4-Bis-(3-methyl-thiophen-2-yl)-but-3-enyl]-piperidine-3-carboxylic acid | (R)-1-[4,4-Bis-(3-methyl-thiophen-2-yl)-but-3-enyl]-piperidine-3-carboxylic acid; hydrochloride | (S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)piperidine-3-carboxylic acid | 1-[4,4-Bis-(3-methyl-4,5-dihydro-thiophen-2-yl)-but-3-enyl]-piperidine-3-carboxylic acid | 1-[4,4-Bis-(3-methyl-thiophen-2-yl)-but-3-enyl]-piperidine-3-carboxylic acid; hydrochloride | A-70569-1 | ABBOTT-70569 | ABBOTT-70569-1 | ABT-569 | CHEMBL1027 | Gabitril | NNC-05-0328 | NO-05-0328 | TIAGABINE | Tiagabine hydrochloride |
Type | Small organic molecule |
Emp. Form. | C20H25NO2S2 |
Mol. Mass. | 375.548 |
SMILES | [#6]-c1ccsc1\[#6](=[#6]/[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6@H](-[#6]-1)-[#6](-[#8])=O)-c1sccc1-[#6] |r| |
Structure |
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