| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50143923 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_67375 (CHEMBL677485) |
|---|
| IC50 | 540±n/a nM |
|---|
| Citation |  Kim, IH; Morisseau, C; Watanabe, T; Hammock, BD Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem47:2110-22 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62613.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P34913 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
|
|
|
|---|
| BDBM50143923 |
|---|
| n/a |
|---|
| Name | BDBM50143923 |
|---|
| Synonyms: | 4-(3-Adamantan-1-yl-ureido)-butyric acid 2-ethoxycarbonyl-ethyl ester | CHEMBL66319 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H32N2O5 |
|---|
| Mol. Mass. | 380.4785 |
|---|
| SMILES | CCOC(=O)CCOC(=O)CCCNC(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:26:17:24:21.20.22,THB:22:23:18:21.26.20,22:21:18:23.25.24,26:21:17.18.25:24| |
|---|
| Structure | 
|
|---|
Search and Browse
