Reaction Details |
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Target | Muscarinic acetylcholine receptor M4 |
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Ligand | BDBM50577263 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2129874 (CHEMBL4839303) |
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IC50 | 4.1±n/a nM |
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Citation | Spock, M; Carter, TR; Bollinger, KA; Han, C; Baker, LA; Rodriguez, AL; Peng, L; Dickerson, JW; Qi, A; Rook, JM; O'Neill, JC; Watson, KJ; Chang, S; Bridges, TM; Engers, JL; Engers, DW; Niswender, CM; Conn, PJ; Lindsley, CW; Bender, AM Discovery of VU6028418: A Highly Selective and Orally Bioavailable M ACS Med Chem Lett12:1342-1349 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M4 |
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Name: | Muscarinic acetylcholine receptor M4 |
Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 53079.31 |
Organism: | Homo sapiens (Human) |
Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
Residue: | 479 |
Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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BDBM50577263 |
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n/a |
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Name | BDBM50577263 |
Synonyms: | CHEMBL4850236 |
Type | Small organic molecule |
Emp. Form. | C23H27F3N4O |
Mol. Mass. | 432.4819 |
SMILES | [H][C@@]12C[C@H](C[C@]1([H])CN(CC1CCOCC1)C2)Nc1ccc(nn1)-c1cc(F)cc(F)c1F |r| |
Structure |
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