| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM50577646 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2130712 (CHEMBL4840141) |
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| IC50 | 100±n/a nM |
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| Citation |  Feng, Y; Park, H; Ryu, JC; Yoon, SO -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. ACS Med Chem Lett12:1546-1552 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM50577646 |
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| n/a |
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| Name | BDBM50577646 |
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| Synonyms: | CHEMBL4845770 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17ClFN5O2S |
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| Mol. Mass. | 457.908 |
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| SMILES | Cc1nc2n(ncc2cc1Nc1c(F)cccc1Cl)-c1csc(c1)C(=O)NC1COC1 |
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| Structure | 
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