Reaction Details |
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Target | Dual specificity mitogen-activated protein kinase kinase 4 |
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Ligand | BDBM50577669 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2130725 (CHEMBL4840154) |
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IC50 | 10000±n/a nM |
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Citation | Kwong, AJ; Pham, TND; Oelschlager, HE; Munshi, HG; Scheidt, KA Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma. ACS Med Chem Lett12:1559-1567 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity mitogen-activated protein kinase kinase 4 |
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Name: | Dual specificity mitogen-activated protein kinase kinase 4 |
Synonyms: | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1 |
Type: | PROTEIN |
Mol. Mass.: | 44294.29 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1460558 |
Residue: | 399 |
Sequence: | MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
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BDBM50577669 |
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n/a |
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Name | BDBM50577669 |
Synonyms: | CHEMBL4861000 |
Type | Small organic molecule |
Emp. Form. | C19H20FN3O2S |
Mol. Mass. | 373.444 |
SMILES | Fc1ccc2c(n[nH]c2c1)-c1ccc(cc1)S(=O)(=O)NC1CCCCC1 |
Structure |
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