Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50577739

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2130818 (CHEMBL4840247)

EC50

>30000±n/a nM

Citation

Pi, Z; Johnson, JA; Meng, W; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Generaux, CN; Wang, T; He, Y; Gordon, DA; Wexler, RR; Finlay, HJ Identification of 6-Hydroxypyrimidin-4(1 ACS Med Chem Lett12:1766-1772 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50577739

n/a

Name

BDBM50577739

Synonyms:

CHEMBL4863722

Type

Small organic molecule

Emp. Form.

C20H26N2O5

Mol. Mass.

374.4308

SMILES

CCCCc1[nH]c(=O)c(C(=O)NCC)c(O)c1-c1c(OC)cccc1OC |(32.08,-11.24,;33.41,-12,;34.74,-11.23,;36.08,-12,;37.41,-11.23,;37.41,-9.68,;38.75,-8.91,;38.75,-7.37,;40.08,-9.68,;41.41,-8.91,;41.42,-7.37,;42.75,-9.69,;44.08,-8.92,;45.41,-9.69,;40.08,-11.22,;41.41,-11.99,;38.75,-11.99,;38.75,-13.52,;40.09,-14.28,;41.42,-13.51,;42.76,-14.27,;40.09,-15.83,;38.76,-16.6,;37.42,-15.83,;37.42,-14.29,;36.09,-13.52,;34.76,-14.29,)|

Structure