Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50577749

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2130818 (CHEMBL4840247)

EC50

0.150000±n/a nM

Citation

Pi, Z; Johnson, JA; Meng, W; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Generaux, CN; Wang, T; He, Y; Gordon, DA; Wexler, RR; Finlay, HJ Identification of 6-Hydroxypyrimidin-4(1 ACS Med Chem Lett12:1766-1772 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50577749

n/a

Name

BDBM50577749

Synonyms:

CHEMBL4854048

Type

Small organic molecule

Emp. Form.

C27H30ClN3O5

Mol. Mass.

511.997

SMILES

CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccc(Cl)cc2)c(O)n1-c1c(OC)cccc1OC |(66.4,-48.76,;67.73,-49.53,;69.07,-48.76,;70.4,-49.53,;71.75,-48.76,;71.75,-47.22,;73.07,-46.46,;73.07,-44.9,;74.4,-47.22,;75.74,-46.44,;75.74,-44.9,;77.07,-47.21,;77.23,-48.74,;78.74,-49.06,;79.51,-47.72,;78.48,-46.58,;81.04,-47.56,;81.94,-48.81,;83.47,-48.66,;84.1,-47.25,;85.63,-47.09,;83.18,-46,;81.66,-46.16,;74.4,-48.74,;75.74,-49.51,;73.08,-49.51,;73.08,-51.04,;74.41,-51.81,;75.74,-51.03,;77.08,-51.8,;74.42,-53.36,;73.08,-54.13,;71.74,-53.36,;71.75,-51.82,;70.41,-51.05,;69.08,-51.82,)|

Structure