Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50577744

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2130819 (CHEMBL4840248)

EC50

1.8±n/a nM

Citation

Pi, Z; Johnson, JA; Meng, W; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Generaux, CN; Wang, T; He, Y; Gordon, DA; Wexler, RR; Finlay, HJ Identification of 6-Hydroxypyrimidin-4(1 ACS Med Chem Lett12:1766-1772 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

42351.61

Organism:

Rattus norvegicus

Description:

ChEMBL_10710

Residue:

377

Sequence:

MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRR
SADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTG
LSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCY
MDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRK
RRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNS
CLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGG
EPMHEKSIPYSQETLVD

BDBM50577744

n/a

Name

BDBM50577744

Synonyms:

CHEMBL4851693

Type

Small organic molecule

Emp. Form.

C28H32N2O5

Mol. Mass.

476.5641

SMILES

CCCCc1[nH]c(=O)c(C(=O)N2CC[C@@H](C2)c2ccccc2)c(O)c1-c1c(OC)cccc1OC |r,wU:14.16,(45.46,-32.95,;46.8,-33.72,;48.13,-32.95,;49.46,-33.71,;50.8,-32.94,;50.8,-31.4,;52.13,-30.63,;52.13,-29.09,;53.46,-31.4,;54.8,-30.63,;54.8,-29.09,;56.13,-31.4,;56.29,-32.92,;57.8,-33.25,;58.57,-31.91,;57.54,-30.77,;60.1,-31.75,;61,-33,;62.53,-32.84,;63.16,-31.44,;62.24,-30.19,;60.72,-30.35,;53.47,-32.93,;54.8,-33.7,;52.13,-33.7,;52.14,-35.23,;53.47,-36,;54.8,-35.22,;56.14,-35.99,;53.48,-37.55,;52.14,-38.32,;50.81,-37.55,;50.81,-36,;49.48,-35.23,;48.14,-36,)|

Structure