Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50577750

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2130819 (CHEMBL4840248)

EC50

0.370±n/a nM

Citation

Pi, Z; Johnson, JA; Meng, W; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Generaux, CN; Wang, T; He, Y; Gordon, DA; Wexler, RR; Finlay, HJ Identification of 6-Hydroxypyrimidin-4(1 ACS Med Chem Lett12:1766-1772 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

42351.61

Organism:

Rattus norvegicus

Description:

ChEMBL_10710

Residue:

377

Sequence:

MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRR
SADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTG
LSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCY
MDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRK
RRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNS
CLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGG
EPMHEKSIPYSQETLVD

BDBM50577750

n/a

Name

BDBM50577750

Synonyms:

CHEMBL4874120

Type

Small organic molecule

Emp. Form.

C26H30N4O5

Mol. Mass.

478.5402

SMILES

CCCCc1nc(=O)c(C(=O)N2CCC(C2)c2ccccn2)c(O)n1-c1c(OC)cccc1OC |(24.48,-6.08,;25.82,-6.85,;27.15,-6.07,;28.49,-6.84,;29.84,-6.07,;29.84,-4.54,;31.16,-3.77,;31.16,-2.21,;32.48,-4.54,;33.82,-3.76,;33.82,-2.22,;35.16,-4.53,;35.32,-6.05,;36.82,-6.37,;37.59,-5.04,;36.56,-3.89,;39.12,-4.88,;40.02,-6.13,;41.55,-5.97,;42.18,-4.56,;41.27,-3.31,;39.74,-3.48,;32.49,-6.06,;33.82,-6.83,;31.16,-6.82,;31.16,-8.36,;32.5,-9.12,;33.83,-8.35,;35.16,-9.11,;32.5,-10.67,;31.16,-11.45,;29.83,-10.68,;29.83,-9.13,;28.5,-8.36,;27.17,-9.13,)|

Structure