| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK2 |
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| Ligand | BDBM50579217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2134723 (CHEMBL4844333) |
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| IC50 | 40±n/a nM |
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| Citation |  Huang, PQ; Boren, BC; Hegde, SG; Liu, H; Unni, AK; Abraham, S; Hopkins, CD; Paliwal, S; Samatar, AA; Li, J; Bunker, KD Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer. J Med Chem64:13004-13024 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK2 |
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| Name: | Serine/threonine-protein kinase PLK2 |
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| Synonyms: | PLK2 | PLK2_HUMAN | Polo-Like Kinase 2 | SNK | Serine/threonine-protein kinase PLK2 | Serine/threonine-protein kinase SNK | Serum-inducible kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 78259.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PLK2 was expressed as GST-fusion protein using baculovirus expression system. GST-PLK2 was purified by using glutathione sepharose chromatography. |
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| Residue: | 685 |
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| Sequence: | MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH
HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP
EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI
CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP
SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA
KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL
QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR
GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD
KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL
YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL
LMSGCSSELKNRMEYALNMLLQRCN
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| BDBM50579217 |
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| n/a |
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| Name | BDBM50579217 |
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| Synonyms: | CHEMBL4871593 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34N8O2 |
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| Mol. Mass. | 526.6327 |
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| SMILES | CCC1(O)CCc2ccc(nc12)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12 |
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| Structure | 
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