| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatitis A virus cellular receptor 2 |
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| Ligand | BDBM50579454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135392 (CHEMBL4845002) |
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| Ki | 970±n/a nM |
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| Citation |  Rietz, TA; Teuscher, KB; Mills, JJ; Gogliotti, RD; Lepovitz, LT; Scaggs, WR; Yoshida, K; Luong, K; Lee, T; Fesik, SW Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3). J Med Chem64:14757-14772 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatitis A virus cellular receptor 2 |
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| Name: | Hepatitis A virus cellular receptor 2 |
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| Synonyms: | CD_antigen=CD366 | HAVCR2 | HAVR2_HUMAN | HAVcr-2 | Hepatitis A virus cellular receptor 2 | T-cell immunoglobulin and mucin domain-containing protein 3 | T-cell immunoglobulin mucin receptor 3 | T-cell membrane protein 3 | TIM-3 | TIM3 | TIMD-3 | TIMD3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33391.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119972 |
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| Residue: | 301 |
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| Sequence: | MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPV
FECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMND
EKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLA
NELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQNLSLI
SLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEEPNEYYCYVSSRQQPSQPLGCRFAM
P
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| BDBM50579454 |
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| n/a |
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| Name | BDBM50579454 |
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| Synonyms: | CHEMBL4868118 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClN5O4S |
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| Mol. Mass. | 433.869 |
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| SMILES | COc1cc(ccc1NS(C)(=O)=O)-c1cc2c3nc(C)nn3c(=O)[nH]c2cc1Cl |
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| Structure | 
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