| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50146614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65487 |
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| IC50 | 6.2±n/a nM |
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| Citation |  Funk, OF; Kettmann, V; Drimal, J; Langer, T Chemical function based pharmacophore generation of endothelin-A selective receptor antagonists. J Med Chem47:2750-60 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50146614 |
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| n/a |
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| Name | BDBM50146614 |
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| Synonyms: | 2-Methyl-5-(3-oxazol-5-yl-phenylsulfamoyl)-furan-3-carboxylic acid methyl ester | CHEMBL367093 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N2O6S |
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| Mol. Mass. | 362.357 |
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| SMILES | COC(=O)c1cc(oc1C)S(=O)(=O)Nc1cccc(c1)-c1cnco1 |
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| Structure | 
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