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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Ligand | BDBM50579957 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2146090 (CHEMBL5030370) | ||
| IC50 | 93±n/a nM | ||
| Citation |  Leenders, RGG; Brinch, SA; Sowa, ST; Amundsen-Isaksen, E; Galera-Prat, A; Murthy, S; Aertssen, S; Smits, JN; Nieczypor, P; Damen, E; Wegert, A; Nazaré, M; Lehtiö, L; Waaler, J; Krauss, S Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem64:17936-17949 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Poly [ADP-ribose] polymerase tankyrase-2 | |||
| Name: | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Synonyms: | (ARTD6 or PARP5b) | PARP5B | Poly [ADP-ribose] polymerase tankyrase-2 | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | TPoly [ADP-ribose] polymerase tankyrase-2 | Tankyrase 2 | Tankyrase II | Tankyrase-2 | Tankyrase-2 (TNKS-2) | Tankyrase-2 (TNKS2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 126937.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9H2K2 | ||
| Residue: | 1166 | ||
| Sequence: |
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| BDBM50579957 | |||
| n/a | |||
| Name | BDBM50579957 | ||
| Synonyms: | CHEMBL5087490 | US11926614, Example 91 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H18FN7O | ||
| Mol. Mass. | 415.423 | ||
| SMILES | Fc1ccccc1-n1c(nnc1-c1cnccn1)[C@H]1C[C@@H](C1)NC(=O)c1ccccn1 |r,wU:20.25,wD:18.20,(25.66,-37.04,;25.04,-38.44,;25.94,-39.68,;25.32,-41.09,;23.79,-41.25,;22.89,-40.01,;23.52,-38.6,;22.62,-37.37,;23.1,-35.9,;21.84,-34.99,;20.61,-35.9,;21.08,-37.37,;20.18,-38.6,;20.8,-40,;19.9,-41.24,;18.37,-41.08,;17.75,-39.67,;18.65,-38.44,;24.56,-35.42,;25.93,-36.12,;26.64,-34.75,;25.26,-34.04,;28.11,-34.28,;28.43,-32.77,;27.28,-31.73,;29.89,-32.29,;30.2,-30.78,;31.67,-30.3,;32.82,-31.33,;32.5,-32.84,;31.04,-33.32,)| | ||
| Structure | 
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