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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Ligand | BDBM50579962 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2146090 (CHEMBL5030370) | ||
| IC50 | 5.8±n/a nM | ||
| Citation |  Leenders, RGG; Brinch, SA; Sowa, ST; Amundsen-Isaksen, E; Galera-Prat, A; Murthy, S; Aertssen, S; Smits, JN; Nieczypor, P; Damen, E; Wegert, A; Nazaré, M; Lehtiö, L; Waaler, J; Krauss, S Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem64:17936-17949 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Poly [ADP-ribose] polymerase tankyrase-2 | |||
| Name: | Poly [ADP-ribose] polymerase tankyrase-2 | ||
| Synonyms: | (ARTD6 or PARP5b) | PARP5B | Poly [ADP-ribose] polymerase tankyrase-2 | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | TPoly [ADP-ribose] polymerase tankyrase-2 | Tankyrase 2 | Tankyrase II | Tankyrase-2 | Tankyrase-2 (TNKS-2) | Tankyrase-2 (TNKS2) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 126937.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9H2K2 | ||
| Residue: | 1166 | ||
| Sequence: |
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| BDBM50579962 | |||
| n/a | |||
| Name | BDBM50579962 | ||
| Synonyms: | CHEMBL5089832 | US11926614, Example 124 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H24N8O2 | ||
| Mol. Mass. | 492.5319 | ||
| SMILES | CCOc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccnc3cccnc23)n1-c1ccccn1 |r,wU:15.18,wD:13.13,(-.25,-14.1,;.65,-12.85,;2.18,-13.02,;3.08,-11.77,;4.62,-11.93,;5.52,-10.69,;4.9,-9.3,;3.37,-9.13,;2.46,-10.37,;5.79,-8.06,;5.32,-6.59,;6.56,-5.68,;7.82,-6.59,;9.28,-6.11,;10.65,-6.81,;11.36,-5.44,;9.98,-4.73,;12.83,-4.97,;13.15,-3.46,;12,-2.42,;14.62,-2.98,;14.93,-1.47,;16.39,-.98,;17.55,-2.02,;17.23,-3.53,;18.37,-4.56,;18.05,-6.06,;16.58,-6.54,;15.44,-5.5,;15.76,-4,;7.34,-8.06,;8.24,-9.3,;7.61,-10.7,;8.51,-11.94,;10.04,-11.78,;10.66,-10.37,;9.76,-9.14,)| | ||
| Structure | 
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