Ki Summary

Reaction Details

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Target

GTPase KRas

Ligand

BDBM50579989

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2146126 (CHEMBL5030406)

IC50

12.0±n/a nM

Citation

Rosse, G A Series of Pyrazole Analogs Binding to KRASG12C as Potential Cancer Treatment. ACS Med Chem Lett13:11-12 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

GTPase KRas

Name:

GTPase KRas

Synonyms:

Type:

PROTEIN

Mol. Mass.:

21656.10

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1476955

Residue:

189

Sequence:

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM50579989

n/a

Name

BDBM50579989

Synonyms:

CHEMBL5080777

Type

Small organic molecule

Emp. Form.

C31H34ClN5O2

Mol. Mass.

544.087

SMILES

Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc(CC(C)(C)O)cc1)-c1c(Cl)c(C)cc2[nH]ncc12 |(8.18,-31.59,;9.64,-31.11,;10.89,-32.01,;12.14,-31.1,;11.65,-29.64,;10.11,-29.64,;9.21,-28.4,;9.45,-26.87,;7.93,-26.63,;7.69,-28.16,;8.32,-25.14,;6.83,-24.74,;6.43,-26.24,;6.06,-23.41,;6.82,-22.08,;4.52,-23.42,;3.74,-22.08,;13.6,-31.57,;14.73,-30.54,;16.2,-31,;16.53,-32.51,;18,-32.98,;18.33,-34.49,;19.79,-34.95,;17.19,-35.52,;18.72,-35.97,;15.39,-33.55,;13.92,-33.08,;10.91,-33.55,;9.58,-34.32,;8.25,-33.55,;9.58,-35.87,;8.24,-36.63,;10.91,-36.64,;12.24,-35.86,;13.71,-36.33,;14.62,-35.09,;13.71,-33.84,;12.24,-34.31,)|

Structure