Ki Summary

Reaction Details

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Target

GTPase KRas

Ligand

BDBM50579990

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2146126 (CHEMBL5030406)

IC50

26±n/a nM

Citation

Rosse, G A Series of Pyrazole Analogs Binding to KRASG12C as Potential Cancer Treatment. ACS Med Chem Lett13:11-12 (2022) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

GTPase KRas

Name:

GTPase KRas

Synonyms:

Type:

PROTEIN

Mol. Mass.:

21656.10

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1476955

Residue:

189

Sequence:

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM50579990

n/a

Name

BDBM50579990

Synonyms:

CHEMBL5081366 | US11702409, Example 52b

Type

Small organic molecule

Emp. Form.

C29H30ClN5O3

Mol. Mass.

532.033

SMILES

Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc(OCCO)cc1)-c1c(Cl)c(C)cc2[nH]ncc12 |(30.48,-32.18,;31.94,-31.7,;33.19,-32.6,;34.43,-31.69,;33.95,-30.23,;32.41,-30.23,;31.51,-28.99,;31.75,-27.46,;30.22,-27.22,;29.99,-28.75,;30.62,-25.73,;29.13,-25.34,;28.73,-26.83,;28.35,-24,;29.12,-22.67,;26.81,-24.01,;26.04,-22.67,;35.9,-32.16,;37.03,-31.13,;38.49,-31.59,;38.83,-33.1,;40.29,-33.57,;41.43,-32.53,;42.9,-33,;44.04,-31.96,;37.69,-34.14,;36.22,-33.67,;33.2,-34.14,;31.88,-34.91,;30.54,-34.14,;31.87,-36.46,;30.54,-37.22,;33.21,-37.23,;34.54,-36.45,;36.01,-36.92,;36.91,-35.68,;36.01,-34.43,;34.54,-34.9,)|

Structure