| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha inhibitor |
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| Ligand | BDBM50580327 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2148056 (CHEMBL5032402) |
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| IC50 | 19200±n/a nM |
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| Citation |  Nowak, RP; Tumber, A; Hendrix, E; Ansari, MSZ; Sabatino, M; Antonini, L; Andrijes, R; Salah, E; Mautone, N; Pellegrini, FR; Simelis, K; Kawamura, A; Johansson, C; Passeri, D; Pellicciari, R; Ciogli, A; Del Bufalo, D; Ragno, R; Coleman, ML; Trisciuoglio, D; Mai, A; Oppermann, U; Schofield, CJ; Rotili, D First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. J Med Chem64:17031-17050 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha inhibitor |
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| Name: | Hypoxia-inducible factor 1-alpha inhibitor |
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| Synonyms: | FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40278.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWT6 |
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| Residue: | 349 |
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| Sequence: | MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR
EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG
QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS
QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA
PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
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| BDBM50580327 |
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| n/a |
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| Name | BDBM50580327 |
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| Synonyms: | CHEMBL5089880 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16N2O3S |
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| Mol. Mass. | 304.364 |
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| SMILES | OC(=O)c1cnc(SCCCCc2ccccc2)[nH]c1=O |
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| Structure | 
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