Reaction Details |
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Target | Lysine-specific demethylase 2A |
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Ligand | BDBM50580319 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2148060 (CHEMBL5032406) |
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IC50 | 24200±n/a nM |
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Citation | Nowak, RP; Tumber, A; Hendrix, E; Ansari, MSZ; Sabatino, M; Antonini, L; Andrijes, R; Salah, E; Mautone, N; Pellegrini, FR; Simelis, K; Kawamura, A; Johansson, C; Passeri, D; Pellicciari, R; Ciogli, A; Del Bufalo, D; Ragno, R; Coleman, ML; Trisciuoglio, D; Mai, A; Oppermann, U; Schofield, CJ; Rotili, D First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. J Med Chem64:17031-17050 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific demethylase 2A |
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Name: | Lysine-specific demethylase 2A |
Synonyms: | AA1-1162 | CXXC8 | F-box and leucine-rich repeat protein 11 | FBL11 | FBL7 | FBXL11 | Homo sapiens lysine demethylase 2A (KDM2A) | JHDM1A | KDM2A | KDM2A_HUMAN | KIAA1004 | Lysine-specific demethylase 2A | Lysine-specific demethylase 2A (KDM2A) | NM_012308 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 132809.04 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 1162 |
Sequence: | MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
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BDBM50580319 |
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n/a |
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Name | BDBM50580319 |
Synonyms: | CHEMBL5083418 |
Type | Small organic molecule |
Emp. Form. | C9H12N2O3S |
Mol. Mass. | 228.268 |
SMILES | CCCCSc1ncc(C(O)=O)c(=O)[nH]1 |
Structure |
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