| Reaction Details |
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 | Report a problem with these data |
| Target | Flavin reductase (NADPH) |
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| Ligand | BDBM50061625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2153628 (CHEMBL5038175) |
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| Kd | 1380±n/a nM |
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| Citation |  Kim, M; Ha, JH; Choi, J; Kim, BR; Gapsys, V; Lee, KO; Jee, JG; Chakrabarti, KS; de Groot, BL; Griesinger, C; Ryu, KS; Lee, D Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX? Reductase B as a Novel Thrombocytopenia Therapeutic Target. J Med Chem65:2548-2557 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Flavin reductase (NADPH) |
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| Name: | Flavin reductase (NADPH) |
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| Synonyms: | 1.3.1.24 | 1.5.1.30 | BLVRB | BLVRB_HUMAN | BVR-B | Biliverdin reductase B | Biliverdin-IX beta-reductase | FLR |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22123.63 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_100283 |
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| Residue: | 206 |
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| Sequence: | MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAAD
VDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTK
VPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHD
LGHFMLRCLTTDEYDGHSTYPSHQYQ
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|
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| BDBM50061625 |
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| n/a |
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| Name | BDBM50061625 |
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| Synonyms: | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid | Am 80 | CHEMBL25202 | Tamibarotene | US11744839, Compound of formula 3 | US9963439, AM80 | retinobenzoic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25NO3 |
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| Mol. Mass. | 351.4388 |
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| SMILES | CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12 |
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| Structure | 
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