| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50582354 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2154141 (CHEMBL5038801) |
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| IC50 | 9.2±n/a nM |
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| Citation |  Liang, X; Tang, S; Liu, X; Liu, Y; Xu, Q; Wang, X; Saidahmatov, A; Li, C; Wang, J; Zhou, Y; Zhang, Y; Geng, M; Huang, M; Liu, H Discovery of Novel Pyrrolo[2,3- J Med Chem65:1243-1264 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50582354 |
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| n/a |
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| Name | BDBM50582354 |
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| Synonyms: | CHEMBL5076728 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26FN7O2 |
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| Mol. Mass. | 451.4966 |
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| SMILES | ONC(=O)CCCCCCn1cc(Nc2ncc3ccn(Cc4ccccc4F)c3n2)cn1 |
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| Structure | 
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