| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6 |
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| Ligand | BDBM50583157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2156719 (CHEMBL5041379) |
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| IC50 | 118±n/a nM |
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| Citation |  Yuan, K; Ji, M; Xie, S; Qiu, Z; Chen, W; Min, W; Xia, F; Zheng, M; Wang, X; Li, J; Hou, Y; Kuang, W; Wang, L; Gu, W; Li, Z; Yang, P Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia. J Med Chem65:857-875 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6 |
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| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| BDBM50583157 |
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| n/a |
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| Name | BDBM50583157 |
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| Synonyms: | CHEMBL5082230 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19FN8 |
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| Mol. Mass. | 402.4276 |
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| SMILES | Fc1cnc(Nc2ccc(cn2)N2CCNCC2)nc1-c1ccc2nccnc2c1 |
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| Structure | 
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