| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50152642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302865 (CHEMBL828780) |
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| Ki | 30000±n/a nM |
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| Citation |  Cook, GR; Manivannan, E; Underdahl, T; Lukacova, V; Zhang, Y; Balaz, S Synthesis and evaluation of novel oxazoline MMP inhibitors. Bioorg Med Chem Lett14:4935-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50152642 |
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| n/a |
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| Name | BDBM50152642 |
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| Synonyms: | (4S,5S)-2-(4-Bromo-phenyl)-4-phenylsulfanyl-5-vinyl-4,5-dihydro-oxazole | CHEMBL187808 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14BrNOS |
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| Mol. Mass. | 360.268 |
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| SMILES | Brc1ccc(cc1)C1=N[C@@H](Sc2ccccc2)[C@@H](O1)C=C |t:8| |
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| Structure | 
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