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TargetDual specificity tyrosine-phosphorylation-regulated kinase 2
LigandBDBM50530430
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2158058 (CHEMBL5042808)
IC50 3.0±n/a nM
Citation Weber, CSipos, MPaczal, ABalint, BKun, VFoloppe, NDokurno, PMassey, AJWalmsley, DLHubbard, REMurray, JBenwell, KEdmonds, TDemarles, DBruno, ABurbridge, MCruzalegui, FKotschy, A Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem64:6745-6764 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Name:Dual specificity tyrosine-phosphorylation-regulated kinase 2
Synonyms:DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2
Type:PROTEIN
Mol. Mass.:66690.69
Organism:Homo sapiens (Human)
Description:ChEMBL_1508025
Residue:601
Sequence:
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50530430
n/a
NameBDBM50530430
Synonyms:CHEMBL4460561
TypeSmall organic molecule
Emp. Form.C15H16N6
Mol. Mass.280.3277
SMILESCc1nc2ccc(nc2n1C1CC1)-c1cc(N)nc(N)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: