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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Sgk1 | ||
| Ligand | BDBM268810 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2158996 (CHEMBL5043746) | ||
| IC50 | <2.0±n/a nM | ||
| Citation |  Halland, N; Schmidt, F; Weiss, T; Li, Z; Czech, J; Saas, J; Ding-Pfennigdorff, D; Dreyer, MK; Strübing, C; Nazare, M Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem65:1567-1584 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Sgk1 | |||
| Name: | Serine/threonine-protein kinase Sgk1 | ||
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) | ||
| Type: | Other Protein Type | ||
| Mol. Mass.: | 48954.40 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. | ||
| Residue: | 431 | ||
| Sequence: |
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| BDBM268810 | |||
| n/a | |||
| Name | BDBM268810 | ||
| Synonyms: | US9718825, Example 215 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23ClFN5O4S | ||
| Mol. Mass. | 531.987 | ||
| SMILES | Cc1n[nH]c2nc(nc(OC3CCC(O)CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |(8.24,.5,;7.09,-.53,;7.25,-2.06,;5.85,-2.68,;4.82,-1.54,;3.28,-1.54,;2.51,-.21,;3.28,1.13,;4.82,1.13,;5.59,2.46,;4.82,3.79,;5.59,5.13,;4.82,6.46,;3.28,6.46,;2.51,7.8,;2.51,5.13,;3.28,3.79,;5.59,-.21,;.97,-.21,;.2,-1.54,;-1.34,-1.54,;-2.11,-.21,;-3.65,-.21,;-4.42,-1.54,;-5.19,-2.87,;-3.09,-2.31,;-5.76,-.77,;-5.76,.77,;-7.09,1.54,;-7.09,3.08,;-8.43,.77,;-8.43,-.77,;-7.09,-1.54,;-7.09,-3.08,;-1.34,1.13,;.2,1.13,)| | ||
| Structure | 
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