| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk3 |
|---|
| Ligand | BDBM269003 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2158999 (CHEMBL5043749) |
|---|
| IC50 | 211±n/a nM |
|---|
| Citation |  Halland, N; Schmidt, F; Weiss, T; Li, Z; Czech, J; Saas, J; Ding-Pfennigdorff, D; Dreyer, MK; Strübing, C; Nazare, M Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem65:1567-1584 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Sgk3 |
|---|
| Name: | Serine/threonine-protein kinase Sgk3 |
|---|
| Synonyms: | CISK | Cytokine-independent survival kinase | SGK3 | SGK3_HUMAN | SGKL | Serum/glucocorticoid-regulated kinase 3 | Serum/glucocorticoid-regulated kinase-like |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57110.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1445194 |
|---|
| Residue: | 496 |
|---|
| Sequence: | MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNT
LKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD
SPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAK
RKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVL
DFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHV
VLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPP
FYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE
SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADD
AFVGFSYAPPSEDLFL
|
|
|
|---|
| BDBM269003 |
|---|
| n/a |
|---|
| Name | BDBM269003 |
|---|
| Synonyms: | N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-phenyl]-5-chloro-2-cyano-benzenesulfonamide | US9718825, Example 446 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12ClN7O2S |
|---|
| Mol. Mass. | 425.852 |
|---|
| SMILES | Nc1n[nH]c2nc(ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2C#N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
