| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50584663 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2160291 (CHEMBL5045041) |
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| IC50 | 420±n/a nM |
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| Citation |  Golovanov, A; Zhuravlev, A; Cruz, A; Aksenov, V; Shafiullina, R; Kakularam, KR; Lluch, JM; Kuhn, H; González-Lafont, Ŕ; Ivanov, I -Substituted 5-(1 J Med Chem65:1979-1995 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 75309.71 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | 15-LO enzyme was purified from phenylhydrazine treated rabbits. |
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| Residue: | 663 |
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| Sequence: | MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
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| BDBM50584663 |
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| n/a |
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| Name | BDBM50584663 |
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| Synonyms: | CHEMBL5090671 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22FN3O5S |
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| Mol. Mass. | 435.469 |
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| SMILES | COc1ccc(cc1NS(=O)(=O)NC(=O)OCC(C)C)-c1cc2cc(F)ccc2[nH]1 |
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| Structure | 
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