Reaction Details |
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Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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Ligand | BDBM50585047 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2161460 (CHEMBL5046210) |
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IC50 | 19±n/a nM |
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Citation | Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett13:577-585 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
Type: | Enzyme |
Mol. Mass.: | 69222.24 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y463 |
Residue: | 629 |
Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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BDBM50585047 |
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n/a |
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Name | BDBM50585047 |
Synonyms: | CHEMBL5075335 |
Type | Small organic molecule |
Emp. Form. | C20H21N7O |
Mol. Mass. | 375.427 |
SMILES | CN1Cc2nn(C)cc2-c2cnc3[nH]cc(-c4cnn(CCCC1=O)c4)c3c2 |
Structure |
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