| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, dimeric NADP-preferring |
|---|
| Ligand | BDBM50585954 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2164375 (CHEMBL5049236) |
|---|
| IC50 | 64100±n/a nM |
|---|
| Citation |  Ibrahim, AIM; Batlle, E; Sneha, S; Jiménez, R; Pequerul, R; Parés, X; Rüngeler, T; Jha, V; Tuccinardi, T; Sadiq, M; Frame, F; Maitland, NJ; Farrés, J; Pors, K Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem65:3833-3848 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde dehydrogenase, dimeric NADP-preferring |
|---|
| Name: | Aldehyde dehydrogenase, dimeric NADP-preferring |
|---|
| Synonyms: | AL3A1_HUMAN | ALDH3 | ALDH3A1 | Aldehyde dehydrogenase 3A1 (ALDH3A1) | Aldehyde dehydrogenase family 3 member A1 (ALDH3A1) | Aldehyde dehydrogenase family 3 member A1 (ALDH3A1) (Q122A) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50394.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 453 |
|---|
| Sequence: | MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
|
|
|
|---|
| BDBM50585954 |
|---|
| n/a |
|---|
| Name | BDBM50585954 |
|---|
| Synonyms: | CHEMBL5092526 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H12ClNO2 |
|---|
| Mol. Mass. | 225.671 |
|---|
| SMILES | Clc1cc(C=O)ccc1N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
