| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 3 |
|---|
| Ligand | BDBM50586222 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2165468 (CHEMBL5050329) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Carrasco, K; Montersino, C; Derviaux, C; Saez-Ayala, M; Hoffer, L; Restouin, A; Castellano, R; Casassa, J; Roche, P; Pasquier, E; Combes, S; Morelli, X; Collette, Y; Betzi, S CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation. J Med Chem65:5660-5674 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 3 |
|---|
| Name: | Bromodomain-containing protein 3 |
|---|
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 79571.81 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15059 |
|---|
| Residue: | 726 |
|---|
| Sequence: | MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
|
|
|
|---|
| BDBM50586222 |
|---|
| n/a |
|---|
| Name | BDBM50586222 |
|---|
| Synonyms: | CHEMBL5082786 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23N5O4S2 |
|---|
| Mol. Mass. | 509.601 |
|---|
| SMILES | CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccnc3C)n(Cc3ccco3)c(=O)c21 |
|---|
| Structure | 
|
|---|
Search and Browse
