Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50156193 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_310320 (CHEMBL833276) |
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EC50 | 100±n/a nM |
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Citation | Glennon, RA; Bondarev, ML; Khorana, N; Young, R; May, JA; Hellberg, MR; McLaughlin, MA; Sharif, NA Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem47:6034-41 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50156193 |
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n/a |
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Name | BDBM50156193 |
Synonyms: | (1R,2R)-2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-propan-1-ol | CHEMBL188709 |
Type | Small organic molecule |
Emp. Form. | C11H16BrNO3 |
Mol. Mass. | 290.154 |
SMILES | COc1cc([C@@H](O)[C@@H](C)N)c(OC)cc1Br |
Structure |
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