Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM198970 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2170680 (CHEMBL5055814) |
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IC50 | 260±n/a nM |
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Citation | Hopper, AT; Juhl, M; Hornberg, J; Badolo, L; Kilburn, JP; Thougaard, A; Smagin, G; Song, D; Calice, L; Menon, V; Dale, E; Zhang, H; Cajina, M; Nattini, ME; Gandhi, A; Grenon, M; Jones, K; Khayrullina, T; Chandrasena, G; Thomsen, C; Zorn, SH; Brodbeck, R; Poda, SB; Staal, R; Möller, T Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139. J Med Chem64:4891-4902 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68403.50 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q64663 |
Residue: | 595 |
Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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BDBM198970 |
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n/a |
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Name | BDBM198970 |
Synonyms: | BDBM199009 | BDBM199010 | US9221832, 34 |
Type | Small organic molecule |
Emp. Form. | C16H12ClF3N2O2 |
Mol. Mass. | 356.727 |
SMILES | FC(F)(F)c1cccc(CC(=O)NC2COc3ncccc23)c1Cl |
Structure |
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