Reaction Details |
| Report a problem with these data |
Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
---|
Ligand | BDBM50587495 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2172731 (CHEMBL5057865) |
---|
IC50 | 2410±n/a nM |
---|
Citation | Bessho, Y; Akaki, T; Hara, Y; Yamakawa, M; Obika, S; Mori, G; Ubukata, M; Yasue, K; Nakane, Y; Terasako, Y; Orita, T; Doi, S; Iwanaga, T; Fujishima, A; Adachi, T; Ueno, H; Motomura, T Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem52:0 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
---|
Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
Synonyms: | PDHK2 | PDK2 | PDK2_HUMAN | Pyruvate dehydrogenase kinase 2 (PDK2) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK2) |
Type: | Enzyme |
Mol. Mass.: | 46153.78 |
Organism: | Homo sapiens (Human) |
Description: | Q15119 |
Residue: | 407 |
Sequence: | MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVR
LANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIR
NRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST
NPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVY
VPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYL
KALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
|
|
|
BDBM50587495 |
---|
n/a |
---|
Name | BDBM50587495 |
Synonyms: | CHEMBL5070430 |
Type | Small organic molecule |
Emp. Form. | C18H20N4 |
Mol. Mass. | 292.3782 |
SMILES | Cc1nc(N2CCCC2)c2c(n1)[nH]c1c(cccc21)C1CC1 |
Structure |
|