Reaction Details |
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Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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Ligand | BDBM50587490 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2172732 (CHEMBL5057866) |
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IC50 | 462±n/a nM |
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Citation | Bessho, Y; Akaki, T; Hara, Y; Yamakawa, M; Obika, S; Mori, G; Ubukata, M; Yasue, K; Nakane, Y; Terasako, Y; Orita, T; Doi, S; Iwanaga, T; Fujishima, A; Adachi, T; Ueno, H; Motomura, T Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem52:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
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Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
Synonyms: | PDHK4 | PDK4 | PDK4_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 4 (PDK4) | Pyruvate dehydrogenase kinase isoform 4 |
Type: | Enzyme |
Mol. Mass.: | 46469.71 |
Organism: | Homo sapiens (Human) |
Description: | Q16654 |
Residue: | 411 |
Sequence: | MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQE
LPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
IKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIF
SDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIH
IVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPL
RIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDA
IIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
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BDBM50587490 |
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n/a |
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Name | BDBM50587490 |
Synonyms: | CHEMBL5080906 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O |
Mol. Mass. | 346.4256 |
SMILES | CC(C)Cc1nnc(o1)-c1cc2c(nc1C)[nH]c1c(cccc21)C1CC1 |
Structure |
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