Reaction Details |
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Target | Beta-lactamase TEM |
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Ligand | BDBM50157687 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_430085 (CHEMBL918106) |
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IC50 | 9±n/a nM |
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Citation | Venkatesan, AM; Gu, Y; Dos Santos, O; Abe, T; Agarwal, A; Yang, Y; Petersen, PJ; Weiss, WJ; Mansour, TS; Nukaga, M; Hujer, AM; Bonomo, RA; Knox, JR Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. J Med Chem47:6556-68 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-lactamase TEM |
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Name: | Beta-lactamase TEM |
Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
Type: | Enzyme |
Mol. Mass.: | 31512.33 |
Organism: | Escherichia coli |
Description: | P62593 |
Residue: | 286 |
Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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BDBM50157687 |
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n/a |
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Name | BDBM50157687 |
Synonyms: | (5R,6Z)-6-[(5-methylimidazo[2,1-b][1,3]-benzothiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo-[3.2.0]hept-2-ene-2-carboxylic acid sodium | CHEMBL222866 |
Type | Small organic molecule |
Emp. Form. | C17H10N3NaO3S2 |
Mol. Mass. | 391.399 |
SMILES | Cc1cccc2sc3nc(\C=C4/[C@H]5SC=C(N5C4=O)C(=O)O[Na])cn3c12 |r,c:14| |
Structure |
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