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TargetMetallo-beta-lactamase type 2
LigandBDBM50149467
Substrate/Competitorn/a
Meas. Tech.ChEMBL_430087 (CHEMBL918108)
IC50 240±n/a nM
Citation Venkatesan, AMGu, YDos Santos, OAbe, TAgarwal, AYang, YPetersen, PJWeiss, WJMansour, TSNukaga, MHujer, AMBonomo, RAKnox, JR Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. J Med Chem47:6556-68 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metallo-beta-lactamase type 2
Name:Metallo-beta-lactamase type 2
Synonyms:BLAB_BACFG | Beta-lactamase type II | ccrA | cfiA
Type:PROTEIN
Mol. Mass.:27252.87
Organism:Bacteroides fragilis
Description:ChEMBL_1502123
Residue:249
Sequence:
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVI
NNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYA
NQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGG
CMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVN
QYIESTSKP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50149467
n/a
NameBDBM50149467
Synonyms:(5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,1-b][1,3]thiazol-2-ylmethylene)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium | CHEMBL122450 | Sodium; (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate | sodium (R)-6-[1-(6,7-dihydro-5H-cyclopenta[d]imidazo[2,1-b]thiazol-2-yl)-meth-(Z)-ylidene]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylate
TypeSmall organic molecule
Emp. Form.C15H10N3O3S2
Mol. Mass.344.389
SMILES[O-]C(=O)C1=CS[C@H]2N1C(=O)\C2=C\c1cn2c3CCCc3sc2n1 |t:3|
Structure
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