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TargetInterleukin-2
LigandBDBM50587596
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2173332 (CHEMBL5058466)
IC50 96±n/a nM
Citation Abdel-Magid, AF Dual Inhibition of IL-2-Inducible T-Cell Kinase (ITK) and Tropomyosin Receptor Kinase A (TRKA) as Potential Treatment for Atopic Dermatitis and Other Inflammatory and Autoimmune Diseases. ACS Med Chem Lett12:1889-1891 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interleukin-2
Name:Interleukin-2
Synonyms:IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:Enzyme
Mol. Mass.:17630.05
Organism:Homo sapiens (Human)
Description:P60568
Residue:153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50587596
n/a
NameBDBM50587596
Synonyms:CHEMBL5086824 | US11661419, Example 36 | US20230280220, Example 36
TypeSmall organic molecule
Emp. Form.C24H28N6O3
Mol. Mass.448.5175
SMILES[H][C@@]12C[C@]1(C)Cc1[nH]nc(c1C2)-c1nc2cc(N(C)C(=O)CN3CCOCC3=O)c(C)cc2[nH]1 |r|
Structure
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