Reaction Details |
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Target | Interleukin-2 |
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Ligand | BDBM50587596 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2173332 (CHEMBL5058466) |
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IC50 | 96±n/a nM |
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Citation | Abdel-Magid, AF Dual Inhibition of IL-2-Inducible T-Cell Kinase (ITK) and Tropomyosin Receptor Kinase A (TRKA) as Potential Treatment for Atopic Dermatitis and Other Inflammatory and Autoimmune Diseases. ACS Med Chem Lett12:1889-1891 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-2 |
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Name: | Interleukin-2 |
Synonyms: | IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF |
Type: | Enzyme |
Mol. Mass.: | 17630.05 |
Organism: | Homo sapiens (Human) |
Description: | P60568 |
Residue: | 153 |
Sequence: | MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRML
TFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSE
TTFMCEYADETATIVEFLNRWITFCQSIISTLT
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BDBM50587596 |
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n/a |
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Name | BDBM50587596 |
Synonyms: | CHEMBL5086824 | US11661419, Example 36 | US20230280220, Example 36 |
Type | Small organic molecule |
Emp. Form. | C24H28N6O3 |
Mol. Mass. | 448.5175 |
SMILES | [H][C@@]12C[C@]1(C)Cc1[nH]nc(c1C2)-c1nc2cc(N(C)C(=O)CN3CCOCC3=O)c(C)cc2[nH]1 |r| |
Structure |
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