| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM50197883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2187564 (CHEMBL5099646) |
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| Kd | 9.9±n/a nM |
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| Citation |  Pinheiro, F; Pallarès, I; Peccati, F; Sánchez-Morales, A; Varejão, N; Bezerra, F; Ortega-Alarcon, D; Gonzalez, D; Osorio, M; Navarro, S; Velázquez-Campoy, A; Almeida, MR; Reverter, D; Busqué, F; Alibés, R; Sodupe, M; Ventura, S Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J Med Chem65:14673-14691 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM50197883 |
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| n/a |
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| Name | BDBM50197883 |
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| Synonyms: | CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Compound Tafamidis | Vyndaqel |
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| Type | Small organic molecule |
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| Emp. Form. | C14H7Cl2NO3 |
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| Mol. Mass. | 308.116 |
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| SMILES | OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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