Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50590098 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2194967 (CHEMBL5107327) |
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Ki | 1244±n/a nM |
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Citation | Fernández-Bachiller, MI; Hwang, S; Schembri, ME; Lindemann, P; Guberman, M; Herziger, S; Specker, E; Matter, H; Will, DW; Czech, J; Wagner, M; Bauer, A; Schreuder, H; Ritter, K; Urmann, M; Wehner, V; Sun, H; Nazaré, M Probing Factor Xa Protein-Ligand Interactions: Accurate Free Energy Calculations and Experimental Validations of Two Series of High-Affinity Ligands. J Med Chem65:13013-13028 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50590098 |
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n/a |
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Name | BDBM50590098 |
Synonyms: | CHEMBL5194849 |
Type | Small organic molecule |
Emp. Form. | C21H25ClN4O2S |
Mol. Mass. | 432.967 |
SMILES | CC(C)N1CCC(CC1)NC(=O)c1ccn(Cc2cc(on2)-c2ccc(Cl)s2)c1 |
Structure |
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