Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50057315 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305729 (CHEMBL829401) |
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IC50 | 10600±n/a nM |
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Citation | Gangjee, A; Lin, X CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase. J Med Chem48:1448-69 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 23891.29 |
Organism: | Pneumocystis carinii |
Description: | n/a |
Residue: | 206 |
Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50057315 |
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n/a |
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Name | BDBM50057315 |
Synonyms: | 5-(Naphthalen-1-ylsulfanylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | CHEMBL17479 |
Type | Small organic molecule |
Emp. Form. | C17H15N5S |
Mol. Mass. | 321.4 |
SMILES | Nc1nc(N)c2c(CSc3cccc4ccccc34)c[nH]c2n1 |
Structure |
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