| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TAO1 |
|---|
| Ligand | BDBM50429615 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2198932 (CHEMBL5111448) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Drewry, DH; Potjewyd, FM; Bayati, A; Smith, JL; Dickmander, RJ; Howell, S; Taft-Benz, S; Min, SM; Hossain, MA; Heise, M; McPherson, PS; Moorman, NJ; Axtman, AD Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of ?-Coronaviruses. J Med Chem65:12860-12882 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TAO1 |
|---|
| Name: | Serine/threonine-protein kinase TAO1 |
|---|
| Synonyms: | KIAA1361 | MAP3K16 | MARKK | TAOK1 | TAOK1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 116088.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_774606 |
|---|
| Residue: | 1001 |
|---|
| Sequence: | MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMS
YSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDA
VRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS
ASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQ
SPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMT
LENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHI
QAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEE
ANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQ
ELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKEL
QIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSIN
EMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSL
RRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAF
SHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSM
GVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
|
|
|
|---|
| BDBM50429615 |
|---|
| n/a |
|---|
| Name | BDBM50429615 |
|---|
| Synonyms: | CHEMBL2334586 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H20N4O |
|---|
| Mol. Mass. | 332.399 |
|---|
| SMILES | CC(C)(O)C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
